• SV trafficking is affected in Syn knocked

  2018-10-23

  

  SV trafficking is affected in αSyn knocked out and transgenic mice, suggesting αSyn role in neurotransmission (Esposito et al., 2012). At short time of incubation of neurons with αSyn, the observed increase in SV mobilization and fusion may correlate to the increased calcium influx. Instead, at late

• XL184 br Discussion In this study we demonstrate that more t

  2018-10-23

  

  Discussion In this study, we demonstrate that more than a quarter of AF patients have CKD, and that age, female sex, CHF, previous stroke/TIA and the occurrence of paroxysmal AF were significantly associated with CKD in AF patients. Second, we found a linear association between CrCl and TTR in AF

• A final model is presented to

  2018-10-23

  

  A final model is presented to suggest that the altered microbial composition of the -infected bile duct may promote tumor development. Specifically, the authors propose that infection and colonization of bile ducts with fosters a carcinogenic microenvironment through bacterial metabolic activity, su

• Human lung tissue from eight donors without overt disease

  2018-10-23

  

  Human lung tissue from eight donors “without overt disease, but unsuitable for transplant” was provide by the Life Alliance Organ Recovery Agency. cDNA was obtained from human lung parenchyma and used to amplify regions of CACNA1C known to present splicing variation. Eight splice variant combination

• Although we are investigating potential links between

  2018-10-23

  

  Although we are investigating potential links between these findings and currently hypothesized models of MS pathobiology, ERY studies in MS patients are not without precedence. A report in the 1960s (Raczkiewicz and Leyko, 1966) documented enhanced production of “adenine nucleotides” from ERYs of M

• A long fasting period of

  2018-10-23

  

  A long fasting period of 72h dramatically inhibited first-phase GSIS in our animal study, suggesting that the fasting-dependent decrease in first-phase GSIS might be more important for mammals living in times of scarcity than for humans living in our current time of relative plenty. Insulin halts m

• br Materials and Methods br

  2018-10-23

  

  Materials and Methods Results Discussion Developing reliable methods for postnatal identification of gestational age dating are urgently required. In jurisdictions where access to ultrasound dating is of limited option, postnatal estimations would improve population surveillance in local ar

• In recent years an imbalance in

  2018-10-23

  

  In recent years, an imbalance in the intestinal microbiota composition, also known as gut dysbiosis, has been shown to play an important role in the etiology of obesity and related comorbidities, such as insulin resistance, hyperlipidemia, chronic inflammation, diabetes, NAFLD and atherosclerosis (L

• We also compared protein abundances in

  2018-10-23

  

  We also compared protein abundances in primary Merlin-deficient human meningioma Atglistatin against human meningeal cells, and primary human schwannoma cells against primary human Schwann cells. We identified numerous novel upregulated and downregulated proteins and phospho-proteins, performed Gen

• The nuclear factor one NF family consists of four

  2018-10-23

  

  The nuclear factor one (NF1) family consists of four site-specific transcription factors (NfiA, NfiB, NfiC, and NfiX) that play a large role in the development of a number of organs systems such as the lung and tak1 inhibitor (Grunder et al., 2002; Harris et al., 2015; Hsu et al., 2011; Steele-Perk

• br Funding Sources This work

  2018-10-23

  

  Funding Sources This work was supported by the Meningitis Research Foundation (UK) Grant 802.0 to A.D.O., J.C.P. and L.K.M., the National Health and Medical Research Council of Australia (NHMRC) Program Grants 565526, 1071659 to J.C.P. and M.P.J, NHMRC Project Grant 627142 to J.C.P. and A.D.O., a

• It should be noted that decreased activity

  2018-10-23

  

  It should be noted that decreased activity of complex I, decreased coupling and increased ROS production accompany the aging process in many tissues (Table 1), paralleling the increase in the frequency of senescent kinesin inhibitor in the same tissues (Jurk et al., 2014; Wang et al., 2009). Mitocho

• br Telomere Dysfunction Can Occur

  2018-10-23

  

  Telomere Dysfunction Can Occur Irrespectively of Length So far, the majority of studies have given evidence to senescence as a result of telomere shortening. However, several reports now suggest that telomere dysfunction can also occur in a length-independent manner (Fig. 1). For example, persist

• Since persistent telomeric DNA damage is a

  2018-10-23

  

  Since persistent telomeric DNA damage is a feature of replicative, stress- and oncogene-induced senescence, it has been suggested that unrepaired telomeres provide a source of persistent DDR signaling which is important to the establishment of senescence (Fumagalli et al., 2012). However, damage at

• br Experimental Evidence for an

  2018-10-23

  

  Experimental Evidence for an Interferon Signature in T1D IFNα is known to stimulate expression of class I major histocompatibility complex (MHC-I) molecules at the surface of exposed cells. Hyper-expression of MHC-I molecules on islets along with detection of IFNα in pancreases of T1D patients co

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