• With centralisation timely and efficient distribution networ

  2019-04-26

  

  With centralisation, timely and efficient distribution networks are key. However, mature blood distribution networks are yet to be established in most developing countries. For example, blood donated in Malawi\'s capital Lilongwe is sent to Blantyre (360 km away) for testing at MBTS before it is tra

• br Conclusions br Disclosures br Introduction Since their in

  2019-04-26

  

  Conclusions Disclosures Introduction Since their introduction, at the end of fifties, cardiovascular implantable devices (CIEDs) have widely expanded in number and in their functions [1,2]. The dramatic increase in the number of CIEDs implanted in the last decade is mainly due to the aging

• br Conclusions br Study limitations br Conflict of

  2019-04-26

  

  Conclusions Study limitations Conflict of interest Introduction Dabigatran etexilate, an orally administered pro-drug, is rapidly converted by a serum esterase to dabigatran, a potent, direct, and competitive inhibitor of thrombin. It has an absolute bioavailability of 6.5% and a serum c

• Funding secured by Not applicable Data collection

  2019-04-26

  

  Funding secured by: Not applicable. Data collection: Sheldon M. Singh, MD, Ramanan Kumareswaran, MD. Conflict of interest Acknowledgments Introduction Early repolarization pattern (ERP) is characterized by an elevation greater than 0.1mV of the junction between the end of the QRS complex

• Common and rare SCN A variants may contribute

  2019-04-26

  

  Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian

• Climate change will have far reaching

  2019-04-26

  

  Climate change will have far-reaching effects on how we build, organise, and manage health systems as complex institutions. Yet, to date, these challenges have largely been ignored by the research community. Despite substantial work by WHO on the interface between climate and health, two major confe

• Desde las organizaciones sociales y poblaciones

  2019-04-26

  

  Desde las organizaciones sociales y poblaciones movilizadas, estas protestas marcan el inicio de un nuevo periodo de distanciamiento frente pyk2 inhibitor los actores político-institucionales, en particular el Partido Nacionalista que logró aglutinar electoralmente sus críticas y expectativas de cam

• We established Wt and two Mt p R

  2019-04-26

  

  We established Wt- and two Mt- (p.R308P and p.A350_N351ins8)-GATA2-expressing 32D neurokinin receptor to analyze the cellular effects of Mt-GATA2 (Fig. 3A). Immunofluorescence analysis revealed that Mt-GATA2 showed similar localization in the nucleus as Wt-GATA2 (Fig. 3B). Both Wt- and mutant-GATA2

• Missed cases have been reported who had an

  2019-04-26

  

  Missed cases have been reported who had an initially elevated C5DC concentration that normalized on a repeated sample. Such a result may be caused by secondary carnitine depletion. To avoid carnitine depletion, we propose that the carnitine loading test be used to assist diagnosis of GA-1. Although,

• The diagnosis of PTC based on the

  2019-04-25

  

  The diagnosis of PTC, based on the Modified Dandy Criteria, is made when a patient exhibits an elevated LP opening pressure above 25cm H20 with normal CSF composition and radiologic findings, and no other explanation for the rise in intracranial pressure [6]. The most common presenting symptom occur

• 1-Deoxynojirimycin A possible mechanism of the initiation of

  2019-04-25

  

  A possible mechanism of the 1-Deoxynojirimycin of HSTCL is a prolonged immunosuppressive status which generates the expansion of γδ T-cells recognizing multiple pathogens through excessive antigenic stimulation. Our cases did not have any previous illness related to immunosuppression, recurrent inf

• br The L type calcium channel LTCC in heart consists

  2019-04-25

  

  The L-type calcium channel (LTCC) in heart consists of 4 subunits: α1, β2, α2, and δ [47], encoded by CACNA1C, CACNB2, and CACNA2D, respectively, with the α2 and δ subunits encoded by the gene CANA2D. In 2007, Antzelevitch et al. [48] reported 2 CACNA1C mutations and a CACNB2 mutation from a genot

• br Conflict of interest statement

  2019-04-25

  

  Conflict of interest statement Acknowledgments Funded by the Division of Medical Oncology at Princess Margaret Hospital, Toronto, Canada. No pharmaceutical company funding was received. The authors acknowledge the roles of Esther Lee and Tazmin Usmani in trial coordination and Dr. Ranjeeta Mal

• br Introduction Bone marrow adipocytes are one of the most

  2019-04-25

  

  Introduction Bone marrow adipocytes are one of the most abundant cell types found in bone marrow tissue. They constitute approximately 15% of the bone marrow volume in young adults, rising to 60% by the age of 65 years old [1]. Previously considered as inert space filling cells with little biolog

• SQTS is relatively rare but should

  2019-04-24

  

  SQTS is relatively rare, but should be considered if the QT interval is markedly abbreviated and the ST segment is nearly absent with peaked and symmetrical T waves. Thus far, mutations in 5 different genes have been found, but genetic testing remains investigational because these genes account for

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