• br Introduction Embryonic stem ES cells were first generated

  2018-10-20

  

  Introduction Embryonic stem (ES) nos inhibitor were first generated from mouse embryos in 1981 (Evans and Kaufman, 1981; Martin, 1981), then in the primates (Thomson et al., 1995) including human (Thomson et al., 1998). ES and ES-like cells have also been obtained from other mammalian species (K

• DNA methylation can be passively lost during DNA replication

  2018-10-20

  

  DNA methylation can be passively lost during DNA replication if it is not maintained by DNA methyltransferases (Chen and Riggs, 2011; Li and Zhang, 2014; Moore et al., 2013; Ooi et al., 2009). Besides passive loss due to DNA replication during cell divisions, DNA methylation can also be subject to a

• Numerous groups have shown that in order

  2018-10-20

  

  Numerous groups have shown that in order to serve as viable cell carriers, NSCs must retain their selective tumor-tropic properties, long-term survival capability, and the ability to successfully reach the targeted tissue into which they distribute their payload (Aboody et al., 2000; Ahmed et al., 2

• Background green fluorescence was detected in the lentiviral

  2018-10-20

  

  Background green fluorescence was detected in the lentiviral reprogrammed MML-6838-CL2 iPSC line and a control episomal (non-GFP) reprogrammed iPSC, indicating silencing (Fig. 1B). Pluripotency was confirmed by detecting expression of SOX2, OCT4, SSEA4, TRA1-61 and TRA1-80 pluripotency-associated ma

• br Resource table Resource details The study was approved

  2018-10-20

  

  Resource table. Resource details The study was approved by the Singhealth ethics committee (protocol number SHSIBC-2014-031), and written informed consent was obtained from the patient. 2ml of peripheral blood sample was obtained from a male 64-year-old Parkinson\'s disease patient carrying a he

• br Experimental Procedures br Acknowledgments The authors

  2018-10-20

  

  Experimental Procedures Acknowledgments The authors would like to thank Birgit Linder and Ann-Marie Alborn for excellent technical assistance and the Center for Cellular Imaging and the Electron Microscopy Unit at Gothenburg University for their technical support. The authors would also like t

• Chromatin at mammalian telomeres is underacetylated and shar

  2018-10-20

  

  Chromatin at mammalian telomeres is underacetylated and shares the typical features of other repeat-containing constitutive heterochromatic elements, such as pericentric chromatin. Telomeric repeats are also enriched for H3K9me3, which represents a docking site for the binding of HP1 isoforms (Benet

• Determining whether the specification of most or all cell

  2018-10-20

  

  Determining whether the specification of most, or all, cell lineages occurs within neoblasts is essential for understanding the cellular basis for planarian regeneration. Specifically, at what cellular step in regeneration is the identity of new diltiazem hcl specified? On the basis of prior results

• br Experimental Procedures br Author Contributions br

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction We recently described an animal model in which primary genetic lesions in bone marrow (BM) stromal nmda resulted in abnormal hematopoiesis in mice and the rare development of acute leukemia (Raaijmakers et al., 20

• The role of PGRN in cortical

  2018-10-20

  

  The role of PGRN in cortical neurons is currently not well understood. PGRN exerts neurotrophic properties through a yet-unidentified receptor (De Muynck et al., 2013; Gass et al., 2012; Van Damme et al., 2008). However, a strong link between PGRN and the WNT signaling pathway in neuronal physiology

• We also revealed that p

  2018-10-20

  

  We also revealed that p63 expression is not significantly affected in hESCs by knockdown of the endogenous miR-302/367 cluster (Figure S6). Thus, p63 is unlikely a target of miR-302/367 cluster in hESCs. BNIP3L/Nix belongs to the Bcl-2 family and is a BH3-only proapoptotic factor. Overexpression of

• It has furthermore been speculated whether Sca plays a role

  2018-10-20

  

  It has furthermore been speculated whether Sca-1 plays a role in stem cell self-renewal. Thus, some experiments with Sca-1 −/− knock-out mice investigating hematopoietic and mesenchymal progenitor akt inhibitor have pointed to a role for Sca-1 in self-renewal (Bonyadi et al., 2003; Ito et al., 2003

• br Results br Discussion We examined

  2018-10-20

  

  Results Discussion We examined gene expression in human intestinal tissue across the developmental continuum in order to determine maturity of in-vitro-derived HIOs. Using global RNA expression data obtained by RNA-seq, several different analyses demonstrated that the HIO transcriptome closely

• KU0059436 Yap plays a major role in maintaining the pluripot

  2018-10-20

  

  Yap plays a major role in maintaining the pluripotency of mouse ESCs (mESCs), and LIF is in part responsible for sustaining YAP expression in those KU0059436 (Tamm et al., 2011). In turn, YAP stimulates LIF receptor expression, facilitating mESC competency to respond to LIF. Furthermore, YAP complex

• cox inhibitor br Introduction Neural stem cells NSCs are

  2018-10-20

  

  Introduction Neural stem cells (NSCs) are a class of multipotent cells responsible for generating all types of neural cells in the nervous system and for maintaining the stem cell population by self-renewal (Gage, 2000). The transition of proliferative and multipotent NSCs to fully differentiated

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