• br Discussion This observation reports an unusual associatio

  2019-04-18

  

  Discussion This observation reports an unusual association of LEMS with LGL leukemia occurring in the same patient, and clearly shows that both diseases benefited from LGL leukemia therapy. Methotrexate and steroids rapidly induced hematological complete remission associated with disappearance of

• The electrophysiological mechanisms underlying high frequenc

  2019-04-17

  

  The electrophysiological mechanisms underlying high frequency activity observed in the PLA during SRAF could be reentry (rotor) or focal discharges (triggered activity). To discriminate between these mechanisms, we perfused ryanodine (10–40μM) or caffeine (5mM) to abolish calcium overload-mediated t

• Heat shock facilitates the folding of various proteins

  2019-04-17

  

  Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is

• br We welcome the efforts by Robert Cohen and

  2019-04-17

  

  We welcome the efforts by Robert Cohen and colleagues to promote country-specific targets for post-2015 health goals. Publications from the Consortium of Universities for Global Health () conference included a welcome focus on the building of effective global health education programmes. Histor

• WHO estimates that of people

  2019-04-17

  

  WHO estimates that 30–50% of people with tuberculosis are untreated, in part because of underdiagnosis. Patients with undiagnosed (or diagnosed and untreated) tuberculosis are most likely to transmit infection, so strategies to reduce disease burden should focus on improving the pathway to care for

• br Radiofrequency ablation Application of single radiofreque

  2019-04-17

  

  Radiofrequency ablation Application of single radiofrequency glucosamine sulfate to the earliest atrial activation site during tachycardia terminated the tachycardia and restored sinus rhythm (Fig. 4). Because the local AF in the SVC continued, we confirmed that isolation of the SVC from the RA

• Numerous clinical trials phase II and

  2019-04-17

  

  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

• Introduction Atrial fibrillation AF is the most

  2019-04-17

  

  Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia managed in clinical practice and the most common arrhythmia requiring hospitalization [1,2]. Thromboembolism occurs with similar incidence, regardless of the form of AF [3,4]. AF management includes anticoagulation to preve

• Stigma and discrimination experienced by

  2019-04-17

  

  Stigma and discrimination experienced by sex workers, injection drug users, and men who have sex with men is tough to tackle. Responses need to be tailored to very different circumstances and require interventions on several levels: policy, societal, health system, and individual. There is no magic

• br Deseo y nostalgia el discurso

  2019-04-16

  

  Deseo y nostalgia: el discurso de lo real en la Historia verdadera Más allá de las afirmaciones de verdad y realidad en las que el texto incurre a cada paso; más allá del detalle (en sus usos narratológicos, retóricos y polémicos); más allá de cierta mimesis entendida como artificio y concebida t

• br Conclusiones br LA REVISTA DE

  2019-04-16

  

  Conclusiones LA REVISTA DE FILOSOFÍA Para la época en que se publicaba la Revista de Filosofía, Cultura, Ciencias y Educación, José Ingenieros lideraba una agrupación nucleada en torno NS-398 intereses intelectuales y afinidades personales que recuperaba, aunque con mucha más moderación, forma

• Esta institucionalizaci n penetr en la sociedad por lo

  2019-04-16

  

  Esta institucionalización penetró en la sociedad, por lo que sus integrantes fueron apartándose de las prácticas políticas que pudiesen identificarlos como comunistas. En la etapa posdemocrática, el uso de palabras como filocomunistas o pro-comunistas, convivió con la instauración de los gobiernos e

• In addition further study is required to evaluate

  2019-04-16

  

  In addition, further study is required to evaluate whether identified mutations influence post-translational modifications because they are important mechanism of transcription factors for regulating normal and leukemic hematopoiesis. Authors\' contributions Conflict of interest Acknowledgm

• buy EZ Cap Reagent GG (3\' OMe) Despite the challenges s

  2019-04-16

  

  Despite the challenges, since the Safe Motherhood Initiative was launched almost 30 years ago, international institutions such as the World Bank and WHO, and independent groups such as the Institute for Health Metrics and Evaluation, have developed, published, and continually refined estimates of ma

• br Discussion IUI with controlled ovarian

  2019-04-16

  

  Discussion IUI with controlled ovarian hyperstimulation has been used over the years as a treatment for mild male factor, anovulation, and unexplained infertility. It is less expensive and less invasive than other assisted reproductive techniques. Therefore, these advantages have made the techniq

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