• Our results are consistent with previous findings

  2019-04-18

  

  Our results are consistent with previous findings in other malignancies. Functional assays revealed that ectopic expression of UCA1 promoted cell proliferation and/or reduced cell apoptosis in non-small cell lung cancer [19], breast cancer [18], colorectal cancer [28], and renal cell carcinoma [23].

• Human ether a go go related gene HERG

  2019-04-18

  

  Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium arecoline hydrobromide that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being trans

• Por otro lado cabe subrayar

  2019-04-18

  

  Por otro lado, cabe subrayar que esta “elegía” de Pellicer se asemeja al género precolombino del icnocuicatl, los “Canto[s] de desolación, de orfandad” (Garibay 1992: 89). Según Garibay, estos cantos precolombinos “tienen parentesco con las elegías […] de los poetas de Occidente, en que se canta la

• br Es curioso observar que en el

  2019-04-18

  

  Es curioso observar que en el terreno de la crítica musical, la tarea fundamental es evidentemente depurar la teoría de todo aquello que obstaculiza la formulación precisa de los elementos esenciales de la música. Sin embargo, cuando se trata de estudiar el tema de la música en la literatura, nad

• Repurposing use of approved drugs for new indications or rep

  2019-04-18

  

  Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o

• En este art culo se observar n

  2019-04-18

  

  En este artículo se observarán ciertos puntos de los capítulos IX y X de Paradiso, donde el autor claramente se rehúsa dgat inhibitor definir a sus personajes y sus discursos, para plantear interrogantes y momentos paradigmáticos de esta imposibilidad clasificatoria que era el objetivo (o utopía) de

• En el segundo grupo se ubican los pueblos ind genas

  2019-04-18

  

  En el segundo grupo se ubican los pueblos indígenas y comunidades afectadas por la industria extractiva, los mismos que han protagonizado intensas y masivas protestas en puntos tan disímiles del territorio nacional como Cajamarca, Arequipa, Piura o la Amazonía. Se trata de diversas poblaciones que o

• br Discussion This observation reports an unusual associatio

  2019-04-18

  

  Discussion This observation reports an unusual association of LEMS with LGL leukemia occurring in the same patient, and clearly shows that both diseases benefited from LGL leukemia therapy. Methotrexate and steroids rapidly induced hematological complete remission associated with disappearance of

• The electrophysiological mechanisms underlying high frequenc

  2019-04-17

  

  The electrophysiological mechanisms underlying high frequency activity observed in the PLA during SRAF could be reentry (rotor) or focal discharges (triggered activity). To discriminate between these mechanisms, we perfused ryanodine (10–40μM) or caffeine (5mM) to abolish calcium overload-mediated t

• Heat shock facilitates the folding of various proteins

  2019-04-17

  

  Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is

• br We welcome the efforts by Robert Cohen and

  2019-04-17

  

  We welcome the efforts by Robert Cohen and colleagues to promote country-specific targets for post-2015 health goals. Publications from the Consortium of Universities for Global Health () conference included a welcome focus on the building of effective global health education programmes. Histor

• WHO estimates that of people

  2019-04-17

  

  WHO estimates that 30–50% of people with tuberculosis are untreated, in part because of underdiagnosis. Patients with undiagnosed (or diagnosed and untreated) tuberculosis are most likely to transmit infection, so strategies to reduce disease burden should focus on improving the pathway to care for

• br Radiofrequency ablation Application of single radiofreque

  2019-04-17

  

  Radiofrequency ablation Application of single radiofrequency glucosamine sulfate to the earliest atrial activation site during tachycardia terminated the tachycardia and restored sinus rhythm (Fig. 4). Because the local AF in the SVC continued, we confirmed that isolation of the SVC from the RA

• Numerous clinical trials phase II and

  2019-04-17

  

  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

• Introduction Atrial fibrillation AF is the most

  2019-04-17

  

  Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia managed in clinical practice and the most common arrhythmia requiring hospitalization [1,2]. Thromboembolism occurs with similar incidence, regardless of the form of AF [3,4]. AF management includes anticoagulation to preve

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