• It has been proposed that the beneficial

  2018-11-12

  

  It has been proposed that the beneficial effects of cell-based therapies might be mediated via several direct and indirect mechanisms, including recruitment of endogenous progenitors, differentiation into functional cardiomyocytes and vascular cells, induction of angiogenesis, promotion of perfusion

• Our results are in line with previous findings showing that

  2018-11-12

  

  Our results are in line with previous findings showing that cellular senescence negatively correlates with reprogramming efficiency (Banito et al., 2009; Mali et al., 2008; Qin et al., 2007; Zhao and Daley, 2008; Zhao et al., 2008). The expression of p21 is controlled by p53 during the replicative s

• Stemness markers that are induced during reprogramming are d

  2018-11-12

  

  Stemness markers that are induced during reprogramming are down-regulated during differentiation. The stem cell line was induced to undergo differentiation in normoxia and POU5F1, SOX2 and NANOG expression decreased between day 0 (undifferentiated state) and day 21 of the differentiation process (Fi

• Alternative approaches to LV are non viral vectors

  2018-11-09

  

  Alternative approaches to LV are non-viral vectors such as RNA or DNA, which are considered safer due to their integration-free nature (Hardee et al., 2017). However, manufacturing RNA is expensive and difficult because RNA has a propensity to degrade (Yin et al., 2014). On the other hand, DNA plasm

• Our behavioral work showed that the aPKC CBP pathway

  2018-11-09

  

  Our behavioral work showed that the aPKC-CBP pathway is required for hippocampal-dependent fear memory formation in mature adult mice (6 months old) but not young adult mice (3 months old). This observation correlates well with the age-dependent functions of the aPKC-CBP pathway in maintaining hippo

• br The corresponding number of trajectories is ten at

  2018-11-09

  

  The corresponding number of trajectories is ten at h=3d= 1.2mm, and the ‘useful’ area increases: After choosing relative position of the emitter and lens end, calculations were done of how to transport and focus the beam by the lens. It was again implemented with the use of the program ‘Simion7

• These findings are particularly important when you take into

  2018-11-09

  

  These findings are particularly important when you take into account the health selection process with respect to the incarcerated and noninstitutionalized populations for each group. Consider the values presented in Table 1 that describe the prevalence of each health problem for black and white men

• It seems reasonable to conclude

  2018-11-09

  

  It seems reasonable to conclude that the Dutch, who exhibit an independent self-construal and are strongly individualistic, use the occasion of helping colleagues as a way to express their pride publicly and standout. This interpretation is consistent with the emotional syndrome description of North

• br Late Cretaceous magmatism mineralization geochronological

  2018-11-09

  

  Late Cretaceous magmatism–mineralization geochronological frameworks in southeast Yunnan and northeast Vietnam The tin polymetallic mineralization and related igneous rocks in the western South China Block have attracted some interests in past decades (Tu et al., 1984; Xie et al., 1984; 308 Geolo

• From the signal processing transform point of

  2018-11-09

  

  From the signal processing transform point of view [9], the Fourier transform (FT) has been applied widely in many scientific disciplines, and has played important role in almost all the science and technology domains. However, with the extension of research objects and scope, FT has been discovered

• We demonstrate here that DOK activated the ligand dependent

  2018-11-09

  

  We demonstrate here that DOK1 activated the ligand-dependent transcriptional activity of PPARγ and inhibited activation of the human c-FOS promoter downstream of RAS, resulting in reduced cell proliferation. This anti-tumor mechanism was allocated to protein domains and subcellular compartmentalizat

• The extracellular matrix ECM is important for

  2018-11-09

  

  The extracellular matrix (ECM) is important for the integrity of the aortic wall and mutations in ECM genes such as Fibulin-4 and Fibrillin-1 hence lead to aneurysm formation. Genetic studies in Fibulin-4 and Fibrillin-1 mutant mice implicated dysregulation of the TGF-β pathway as an important hallm

• It has previously been hypothesised that iron

  2018-11-09

  

  It has previously been hypothesised that iron supplementation increases malaria susceptibility by increasing the availability of \'s preference for young RBCs (). observed significant shifts in RBC populations following iron supplementation, finding younger RBCs are most prevalent at Day 49 post ir

• Only two studies have investigated whether pubertal factors

  2018-11-09

  

  Only two studies have investigated whether pubertal factors also influence white matter microstructure in adolescence, in addition to effects of age. The first study looked at RD in white matter tracts in males and females aged 8–28 years (n = 114, 63 females), and explored whether pubertal effects

• What has called our attention is the little

  2018-11-09

  

  What has called our attention is the little dissemination of the reality of the Central American countries, because no one in the previous revisions has developed the true reality of such countries, amplifying therefore, the possibilities of sleep medicine in our continent. Besides, there seems to b

16455 records 1077/1097 page Previous Next First page 上5页 10761077107810791080 下5页 Last page