• What has called our attention is the little

  2018-11-09

  

  What has called our attention is the little dissemination of the reality of the Central American countries, because no one in the previous revisions has developed the true reality of such countries, amplifying therefore, the possibilities of sleep medicine in our continent. Besides, there seems to b

• br Conformaci n del sector tecnol gico de

  2018-11-09

  

  Conformación del sector tecnológico de las baterías Para conceptualizar protein kinase la batería o cualquier otra tecnología en un diseño, se puede pensar que la tecnología es una combinación de elementos (N) y conexiones (K) (Potts:2001). Las combinaciones de estos elementos son las conexiones,

• br M xico variaci n anual del pib

  2018-11-09

  

  México: variación anual del pib trimestral real Fuente: elaboración propia con SC 144 en datos de inegi. México: índice general de precios al consumidor Fuente: elaboración propia con base en datos de inegi. Fuente: elaboración propia con base en datos de inegi. Fuente: elaboración p

• br A tough nut to crack Wicksell

  2018-11-09

  

  A tough nut to crack Wicksell\'s (1890) Norwegian article on “Empty stomachs – and full warehouses” was written in June that year in Paris. His visit to France closed the long jnk inhibitors of economic studies abroad he had started in 1885–1886, which included as well stays in London, Strasbourg

• The essential autophagy gene beclin BECN is a haploinsuffici

  2018-11-09

  

  The essential autophagy gene beclin 1 (BECN1) is a haploinsufficient tumor suppressor (Liang et al., 1999; Qu et al., 2003; Yue et al., 2003) that is also located on the breast cancer tumor susceptibility chromosomal locus 17q21, ~150kb centromeric to BRCA1 (Aita et al., 1999). Monoallelic loss of B

• Although technological improvements in terms of specimen acq

  2018-11-09

  

  Although technological improvements in terms of specimen acquisition and processing have been made, much work remains to be done to ensure the quality of biospecimens and harmonization of tissue collection, processing and storage procedures, attributable largely to the long-standing success of forma

• In recent years several groups have

  2018-11-09

  

  In recent years several groups have attempted to identify specific signatures to distinguish between tuberculosis and sarcoidosis using transcriptomics or gene expression profilings (Koth et al., 2011; Maertzdorf et al., 2012; Berry et al., 2010). Yet, most of these methods led to the discovery of a

• To elucidate the mechanisms by which VEGFC CREB

  2018-11-09

  

  To elucidate the mechanisms by which VEGFC–CREB axis plays a role in vessel formation, we investigated the effect of VEGFC and hypoxia on NOTCH signaling. Our in vitro and in vivo findings indicate that both VEGFC and hypoxia stimulate DLL4–NOTCH1 signaling and these events require the activation of

• In summary we have uncovered the role of

  2018-11-09

  

  In summary, we have uncovered the role of Lyn in mucus hypersecretion in a model of experimental bronchial H-Lys(Ac)-OH.HCl in mice as well as in airway epithelial cells in vitro. Our results show that Lyn overexpression attenuates chronic airway inflammation and ER stress, which are associated wi

• Clinical trials with allogeneic neural cells most often

  2018-11-08

  

  Clinical trials with allogeneic neural Go 6976 most often involve immunosuppressive treatments (Piccini et al., 2005; Krystkowiak et al., 2007; Sandner et al., 2012), although it is still not fully understood how immunogenic these cells are, whether immunosuppression is a prerequisite and the optim

• Unspecific amplification of gene expression exploits informa

  2018-11-08

  

  Unspecific amplification of gene expression exploits information intrinsic to cells, initiating a self-organizing circuitry, where gene expression cascades propagate and interact, much like the propagation of microscopic fluctuations within a critical iron magnet. Unlike an iron magnet, the circuitr

• The effect of taurine increasing NPC number may result from

  2018-11-08

  

  The effect of taurine increasing NPC number may result from a protective action improving cell viability or/and from an increase in proliferation. This was examined by measuring viability by the Trypan blue exclusion and MTT assays, and proliferation by BrdU incorporation. Fig. 2A shows the time cou

• All cell lines demonstrated contribution to tissues represen

  2018-11-08

  

  All cell lines demonstrated contribution to tissues representative of the 3 germ layers in teratoma assays at the end of suspension culture. The H9 line was also examined for in vitro differentiation capacity in EBs formed from day 3 spinner flask cultures with the addition of serum. RT-PCR analyses

• One limitation of using iPSCs is the

  2018-11-08

  

  One limitation of using iPSCs is the inability to carry out studies under genetically defined conditions, leading to increased experimental variability. To overcome these obstacles, we used a zinc-finger-nuclease (ZFN)-mediated gene-editing technique (An et al., 2012; Corti et al., 2012; Li et al.,

• To further verify the corneal progenitor state

  2018-11-08

  

  To further verify the corneal progenitor state of orthopox maturated in CnT-30 medium after induction with SM, we confirmed the protein expression of ABCG2, CK15, and DG-3. These proteins have been previously established as putative progenitor markers of the corneal epithelium (Chen et al., 2004; Da

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