• Introduction Antimicrobial resistance is a growing health th

  2024-05-11

  

  Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of Pefloxacin [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their knowl

• br AR signals and chemosensitivity in urothelial cancer A

  2024-05-11

  

  AR signals and chemosensitivity in urothelial cancer A significant amount of patients with urothelial cancer fail to respond to cisplatin-based systemic chemotherapy, although it remains the mainstay of successful management of advanced disease. However, underlying mechanisms for chemoresistance

• br STAR Methods br Author Contributions br Acknowledgments T

  2024-05-11

  

  STAR★Methods Author Contributions Acknowledgments This study is funded by National Institutes of Health (NIH) Grants NS028901 and DC004450 (to L.O.T.); N.L. Tartar Trust Fellowship (to H.-W.L.); DC014878 to T.S.B. We thank members of the Trussell lab for helpful discussions, Dr. Stephen Dav

• br Experimental section br Results and

  2024-05-11

  

  Experimental section Results and discussion Conclusion Acknowledgement This work was supported by the National Natural Science Foundation of China (Grant Nos. 81401489), the Shanghai Pujiang Program (17PJ1402800) and the Shanghai Sailing Program (Grant No. 14YF1409000). Introduction

• br Preliminary remarks Expression of the transcription facto

  2024-05-11

  

  Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the meclofenamate of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental factors to an

• br There is evidence to suggest that GMF

  2024-05-11

  

  There is evidence to suggest that GMF activities are regulated in vivo by post-translational modification. indeed, there is strong precedent for ADF-homology family proteins being regulated in this manner. Cofilin is inhibited by phosphorylation of a serine residue at its N terminus. This residue

• br Acknowledgments This work was supported by the R D

  2024-05-11

  

  Acknowledgments This work was supported by the R&D Program of the Institutional Research Program of KRICT (SI1701-02), and by the Next generation carbon upcycling project of Ministry of Science and ICT. JSC is kindly grateful to the National Research Council of Science and Technology (NST) for fi

• cholecystokinin receptor The earliest appearance of tumors o

  2024-05-10

  

  The earliest appearance of tumors occurred at 12 months and the latest at 24 months, with an average onset at 18 months (Fig. 1B). This would be roughly equivalent to cancer presenting in a patient between 60 and 70 years of age. In transgenic animals, autotaxin cholecystokinin receptor was relativ

• HG-10-102-01 receptor Suspecting that ACL might regulate the

  2024-05-10

  

  Suspecting that ACL might regulate the expression or activity of myogenic transcription factors, Das knocked down MyoD and found that such intervention abolished the effect of ACL on fast MyHC expression and that, conversely, MyoD overexpression partially rescued reduced fast MyHC expression caused

• We found a protective effect of the GTCC haplotype against

  2024-05-10

  

  We found a protective effect of the GTCC haplotype against ED, which is reflected by its association with increased IIEF in patients with clinical ED. Further studies are required to determine the functional implications of these genetic markers combined in specific haplotypes blocks. Indeed, we fou

• The PDZ domains of DLG interact with

  2024-05-10

  

  The PDZ domains of DLG interact with tumor suppressor proteins, APC and PTEN, as well as with several viral oncoproteins such as the E6 protein present in oncogenic human papillomavirus (reviewed in [177]). It has been reported that overexpression of DLG in fibroblasts impairs the events in the G0/G

• In humans the superior safety

  2024-05-10

  

  In humans, the superior safety profile of lipid-associated formulations is characterized by decreased acute infusion-related reactions and dose-related nephrotoxicity, allowing the administration of larger doses and therefore similar efficacy with fewer administrations. In vitro studies and human cl

• br Conclusions br Acknowledgments br Introduction The

  2024-05-10

  

  Conclusions Acknowledgments Introduction The surface water bodies are affected by effluents containing pollutants from wastewater treatment plants, storm water overflows and run-off from non-point sources like agricultural land and urban city surfaces. This relates to land-based sources occ

• Among all the compounds the novel L derivative d showed

  2024-05-09

  

  Among all the compounds, the novel L-748,337 derivative (23d) showed the potent human β3-AR antagonist activity and high lipolysis inhibitory activity in vitro. The NHS-12-Biotin australia 23d displayed 23-fold more potent β3-AR antagonist activity (EC50 = 0.5117 nM) than that of L-748,337 (EC50 = 

• Adiponectin belongs to the CTRP

  2024-05-09

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

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