• In the present study we showed that LOX metabolites which

  2025-01-27

  

  In the present study, we showed that 15-LOX metabolites, which are the precursors of anti-inflammatory and pro-resolving lipid mediators, were decreased in the unaffected skin area of the OS model rats by comprehensive lipidomics analyses. Furthermore, subsequent microarray analyses demonstrated tha

• Besides one should also consider that all antioxidant

  2025-01-27

  

  Besides, one should also consider that all antioxidant compounds (free soluble or insoluble bounds) exist all together in colon, where radicals and antioxidant compounds react continuously with each other. At this point, after the consumption of antioxidants bound to dietary fiber, they reach the co

• Furthermore different s http www apexbt com

  2025-01-27

  

  Furthermore, different studies have described the APP as useful biomarkers in monitoring the post-ovariohysterectomy period in bitches with pyometra [12,14,52,53], similar to what was observed in queens in the present study. In our study, significant decreases in concentrations of a major (SAA) and

• br Experimental section br Acknowledgements The authors than

  2025-01-27

  

  Experimental section Acknowledgements The authors thank Prof. Yongbing Cao from School of Pharmacy, the Second Military Medical University, for providing the fluconazole-resistant strains of Candida albicans(strain 100 and strain 103). This work was supported by Program for Innovative Research

• Several ceritinib resistant mutations following the second l

  2025-01-26

  

  Several ceritinib-resistant mutations following the second-line treatment of ALK+-NSCLC have been discovered [64]. These mutations include C1156Y, F1174L, and L1152R, which were first observed in crizotinib-resistant tumor samples. The G1202R ceritinib-resistant mutation occurs within the hinge and

• vasopressin receptor antagonists We have previously shown th

  2025-01-26

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor vasopressin receptor antagonists (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to ge

• Structure activity relationships biochemical metabolic

  2025-01-26

  

  Structure–activity relationships [23], [24], [25], [26], biochemical [24], [25], [26], [27], [28], [29], [30], [31], metabolic [19], [27], [28], [29], [30], [31], and molecular [32] investigations have demonstrated that the substrate specificity, as well as other characteristics of T. gondii adenos

• br Difference between ACh and ER

  2025-01-26

  

  Difference between ACh and ER tests There are few reports concerning the provoked spasm between ER and ACh in the same patients [51], [52], [53]. Different mediators may have the potential of different coronary responses. In our experience, spasm provoked by intracoronary injection of ER is foca

• Aurora B is also very important in proper

  2025-01-26

  

  Aurora-B is also very important in proper cytokinesis. In the absence of Aurora-B mediated phosphorylation of Ser72 in vimentin, the two daughter cells remain attached to each other through bridges of cytoplasm; cytokinesis fails [31]. Other Aurora-B dependent proteins that are important for cytokin

• Here we report discovery of highly selective pan Aurora

  2025-01-26

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of Arylquin 1 bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the interaction. To

• As aforementioned this study aimed to design

  2025-01-26

  

  As aforementioned, this study aimed to design, synthesize and investigate aromatase inhibitory and anti-breast cancer activities of N,N′-disubstituted thiourea derivatives. Based on the attractive phenotypic molecule 1, the synthetic N,N′-disubstituted thioureas have been designed including monothio

• Plant defensins are cysteine rich cationic peptides of kDa

  2025-01-24

  

  Plant defensins are cysteine-rich cationic peptides of 5–8 kDa whose mature domain comprises 45 to 54 amino Hutchinson-Gilford syndrome therapy residues, with an isoelectric point around 9. The global fold of plant defensins consists of a cysteine-stabilized motif (CSα/β) made up of an α-helix and

• Earlier studies with SERMs identified that distinct chemical

  2025-01-24

  

  Earlier studies with SERMs identified that distinct chemical scaffolds have the ability to induce unique conformational changes in the ER, resulting in interaction with different cofactor subsets. The same has been demonstrated with SARMs, which induce distinct conformational changes compared to te

• Inhibition of autophagy has been

  2025-01-24

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• Our conclusion was confirmed by

  2025-01-24

  

  Our conclusion was confirmed by two experiments. The addition of aminopeptidase-specific inhibitors at high concentrations allowed us to exclude the possibility of substrate hydrolysis by other proteases present in the samples, for example, endoproteases. After the application of inhibitors, we were

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