• Besides its multiple peripheral effects adiponectin may

  2023-10-27

  

  Besides its multiple peripheral effects adiponectin may ameliorate insulin resistance by acting in the brain, and intracerebroventricular administration of adiponectin in rodents decreases body weight by stimulating energy expenditure [13]. Adiponectin most likely crosses the blood-CSF-barrier (BCB)

• We found that several anticancer drugs inhibit HT receptor c

  2023-10-27

  

  We found that several anticancer drugs inhibit 5-HT3 BI 2536 current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan is used frequently

• We have previously reported that interfering with actin asse

  2023-10-27

  

  We have previously reported that interfering with NPI-0052 assembly dynamics by knocking down cofilin-1 in hMSCs increased polymerized actin that promoted osteoblast cell differentiation through a mechanism of enhancing focal adhesion kinase (FAK), p38 and c-Jun N-terminal kinase (JNK) signaling (C

• br Introduction Myasthenia gravis MG is an autoimmune diseas

  2023-10-27

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease characterised by failure of transmission at the neuromuscular junction (NMJ). In 80–85% of myasthenia gravis patients, the disease is mediated by antibodies to the nicotinic Benzamil receptor (AChR; (Lindstrom et al., 1976). Many invest

• At the last follow up

  2023-10-27

  

  At the last follow-up, nine patients had discontinued pyridostigmine within the first year postoperatively. Only one patient required pyridostigmine at a higher dose, but this was accompanied by successful weaning of prednisolone. None of the 5 patients who were on pyridostigmine treatment alone pri

• Molecular docking is widely used to predict the interaction

  2023-10-27

  

  Molecular docking is widely used to predict the interaction between an enzyme and its inhibitors. This is a computational simulation approach that can be used as a tool to investigate the structure-activity relationship of ACE inhibitory peptides (Goodsell, 2009). It has been recently shown that ACE

• rs G allele was previously associated with

  2023-10-27

  

  rs523349 G allele was previously associated with a decrease in the conversion rate of testosterone to DHT (Beesley et al., 2007). This SRDA52 variant may have a trend towards higher testosterone availability, which according to the US Food and Drug Administration is described as a teratogen of categ

• br The role of cytochrome b with cytochrome P

  2023-10-27

  

  The role of cytochrome b5 with cytochrome P450 17α-hydroxylase/17,20-lyase Conclusion Acknowledgments LLM and RJR wish to thank the Australian Research Council and the National Health and Medical Research Council of Australia for funding. The problem One area of modern medicine that con

• Kidney contributes importantly to the long term blood pressu

  2023-10-26

  

  Kidney contributes importantly to the long-term blood pressure control via regulating sodium homeostasis. Renal proximal tubule (RPT) is one of the most critical segments for sodium reabsorption within kidney and therefore involved in blood pressure adjustment. This process is regulated by numerous

• Introduction Increasing environmental pollution caused

  2023-10-26

  

  Introduction Increasing environmental pollution caused by heavy metals, originating mainly from industrial processes and urban activities, as well as the widespread application of pesticides, fertilizers, manure and sewage sludge, has posed a serious problem for safe food production and become a po

• br Conflict of interest statement br Introduction

  2023-10-26

  

  Conflict of interest statement Introduction Human saliva contains many detoxifying and antioxidant sr 75 australia like glutathione S-transferase, catalase, peroxidase, aldehyde dehydrogenase (ALDH), etc. [1]. Human salivary ALDH (hsALDH) protects individuals from toxic aldehydes contained in

• br Introduction Psychostimulant abuse and addiction remain

  2023-10-26

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• br Methods br Results br Discussion br Acknowledgements br T

  2023-10-26

  

  Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V

• Our in vitro data show that CyaA does not

  2023-10-26

  

  Our in vitro data show that CyaA does not play a critical role in the bacterial adherence to mammalian cells. This observation is in contrast to previous studies that reported a role for CyaA in FHA-mediated adherence of B. pertussis bacteria to the respiratory epithelial 961 [37,38]. This discrepa

• br Introduction Myasthenia gravis MG

  2023-10-26

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against K-7174 receptor (AChR) [1]. In AChR negative MG patients antibo

16602 records 260/1107 page Previous Next First page 上5页 256257258259260 下5页 Last page