• Excessive extracellular glutamate can be removed from brain

  2022-04-20

  

  Excessive extracellular glutamate can be removed from Viroptic interstitial fluids to the blood plasma for the maintenance of proper extracellular glutamate homeostasis in the mammalian central nervous system [[5], [6], [7]]. The glutamate concentration in the blood plasma increases in case of ische

• 3CAI Ionotropic glutamate receptors GluRs are ligand gated i

  2022-04-20

  

  Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio

• This work was supported by the National Natural Science Foun

  2022-04-20

  

  This work was supported by the National Natural Science Foundation of China (Grants 81471101 and 81870852), the Natural Science Foundation of Jiangsu Province (Grant BK20181146), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grants 18KJA320007 and 17KJB320018)

• The effect of exercise on plasma ghrelin

  2022-04-19

  

  The effect of exercise on plasma ghrelin has previously been investigated mostly in humans using exercise regimens such as treadmill running, cycling, and rowing, and also in a few rodent studies and in some other animal models. While many of these clinical studies and some preclinical studies demon

• br Materials and methods br Conflicts of interest Some of

  2022-04-19

  

  Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He

• br Introduction Hepatocyte injury initiates and facilitates

  2022-04-19

  

  Introduction Hepatocyte injury initiates and facilitates inflammation in the course of liver disease progression. Thus, understanding the regulatory basis for sensing and responding to damage-associated inflammatory processes in the liver’s parenchymal cells is a primary issue in liver pathophysi

• Our results are consistent with the hypothesis

  2022-04-19

  

  Our results are consistent with the hypothesis that reduced Fas-mediated apoptosis in maternally activated T-lymphocytes could result in insufficient trophoblast invasion of the spiral β-Glycerophosphate sodium salt hydrate as the activated T-lymphocytes become able to enhance the destruction of th

• The EZH overexpression group exhibited upregulated

  2022-04-19

  

  The EZH2 overexpression group exhibited upregulated CEP55 expression but downregulated methylation, suggesting that changes in EZH2 expression in lung adenocarcinoma result in differences of CEP55 methylation and expression. Moreover, according to TCGA database and GSE27262 chip data, CEP55 expressi

• Liposomes that are less than nm in diameter

  2022-04-19

  

  Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by growth hormone secretagogue (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Even sma

• Our extensive preliminary data suggest that

  2022-04-19

  

  Our extensive preliminary data suggest that the loss of p300 (and resulting H3K27ac) is related to inorganic arsenic related diseases. Therefore, it may open a new avenue for alleviating the consequence of H3K27ac, for example, via boosting CBP enzymatic activity for at least partially compensating

• br Funding This study was supported

  2022-04-19

  

  Funding This study was supported by grants-in-aid for scientific research from the Japan Society for Promotion of Science (grant 16K186462 to Dr. Tomizawa, grant 16K19989 to Dr. Kobayashi, and grant 16H05433 to Dr. Mitsudomi) and a research grant from Boehringer-Ingelheim (to T. Mitsudomi). Co

• RS testing has been extensively validated in patients with e

  2022-04-19

  

  RS testing has been extensively validated in patients with early stage, ER+, HER2− patients. TAILORx, a randomized controlled trial to evaluate the role of adjuvant chemotherapy by RS, found no recurrence or survival benefit to the addition of chemotherapy to endocrine therapy in patients with inter

• To prevent toxicity of free hemoglobin as well as its

  2022-04-19

  

  To prevent toxicity of free hemoglobin as well as its degradation metabolites heme and free iron, several scavenger proteins and degradation enzymes protect the body. Haptoglobin (Hp) is the most well described hemoglobin scavenging protein that binds free hemoglobin and transports it to macrophage

• br GPR a G protein coupled receptor GPCR was discovered

  2022-04-18

  

  GPR35, a G protein-coupled receptor (GPCR), was discovered and classified as an orphan GPCR in 1998 and deorphanized in 2006 by the discovery of kynurenic Zerumbone as the endogenous agonist. Since its discovery, limited references on the GPR35 receptor have appeared, due in part to a scarcity of

• Mapping and separation of the anti GlyT C epitopes allowed

  2022-04-18

  

  Mapping and separation of the anti-GlyT1C epitopes allowed us to verify the existence of calpain cleavage sites in isolated mouse synaptosomes. In order to allow calcium to enter the intrasynaptosomal compartment and activate endogenous calpain, we incubated synaptosomes in hypoosmotic high (200μM)

16527 records 473/1102 page Previous Next First page 上5页 471472473474475 下5页 Last page