• A genomic DNA sequence was

  2021-03-02

  

  A genomic DNA sequence was retrieved (Scaffold_30) from the fugu genomic database ( v3.0), which encodes the homolog of CXCL8 of many other vertebrates and specific primers CXCL8F1 and CXCL8R1 () were designed for 3′-RACE and 5′-RACE PCR, respectively. First-strand thymus cDNA was used as template.

• Elevated homocysteine has been considered to be a risk facto

  2021-03-02

  

  Elevated homocysteine has been considered to be a risk factor for vascular dysfunction, vascular disease, and preeclampsia , . The methionine-homocysteine metabolism is responsible for supplying COMT with the methyl-group donor (-adenosyl methionine; SAM) necessary for 2-ME synthesis, and alteration

• Selective inhibitor of phosphodiesterase type PDE I is

  2021-03-02

  

  Selective inhibitor of phosphodiesterase type 5 (PDE5I) is commonly used for ED treatment. PDE5I exhibits its vasodilatory effect by inhibiting the degradation of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle and allows increased blood flow for penile tumescence. Udenafil (D

• br Progestogens and autoimmune diseases br Conclusion br Tak

  2021-03-02

  

  Progestogens and autoimmune diseases Conclusion Take-home messages Introduction The benefits of breastfeeding for both women and their infants are considerable [1], [2], [3]. The World Health Organization (WHO) recommends infants breastfeed exclusively during the first months of life [4]

• Additionally both in vitro and

  2021-03-02

  

  Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bindi

• Importantly our in vivo data fit to

  2021-03-02

  

  Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 L002 mg levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016). We b

• br Conclusions br Introduction The

  2021-03-01

  

  Conclusions Introduction The terms endocrine active and endocrine disruptive have been used to describe an ever-expanding list of naturally-occurring and synthetic compounds that interact with mammalian hormonal systems, and in particular, the reproductive system. These compounds have been ass

• br A brief introduction to

  2021-03-01

  

  A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating at the end of your rope (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be c

• The efficacy of A in the ob

  2021-03-01

  

  The efficacy of A-922500 in the ob/ob mouse model is of particular interest for two reasons. One of the most striking features of the DGAT-1 deficient mouse phenotype is the resistance to diet-induced obesity (Smith et al., 2000). However, mao inhibitors of DGAT-1 in leptin deficient ob/ob mice fai

• Given the excellent in vitro

  2021-03-01

  

  Given the excellent in vitro pharmacology profiles of methyl ester 28 and primary amide 29 efforts were reengaged on neutral analogs of these leads, with a focus on non-amide replacements for the carboxylic Ivabradine HCl functionality of 1. Acetonitrile 49 was found to have a good balance of DGAT-

• The present study provides the first evidence

  2021-03-01

  

  The present study provides the first evidence that the human uroepithelial PR-171 synthesis in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuoles were

• The most important finding in the present study is that

  2021-03-01

  

  The most important finding in the present study is that the EKR1/2-Egr-1 signaling pathway might be involve in the mechanisms underlying CysLT2 receptor-mediated IL-8 production. The signaling profile can be described by the following sequential processes: the agonists (LTC4 and LTD4) activates CysL

• The heterogeneity among studies that investigated the associ

  2021-03-01

  

  The heterogeneity among studies that investigated the association of COMT Val158Met with alexithymia was also significant (Ham et al., 2005; Min et al., 2016; Swart et al., 2011; Zekioglu et al., 2014). The healthy status, drug effect, and other demographic variables also influenced one's ability of

• FITC, Fluorescein isothiocyanate sale A previous study repor

  2021-03-01

  

  A previous study reported that it is unlikely that silkworm mounts a general type of immune response to all viruses (Liu et al., 2015). It is not clear whether there is a common pattern of host regulation for silkworm viruses. Spry is a general inhibitor of receptor tyrosine kinases (RTKs), which is

• Another interesting finding regarding substrate selectivity

  2021-03-01

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty HU 308 at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute a maj

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