• Her eldest daughter individual had a normal birth

  2019-10-31

  

  Her eldest daughter (individual 4) had a normal birth and health history in early childhood. She developed contractures of her fourth fingers at 4–5 years of age; these contractures were associated with painless, non-erythematous swelling of the involved joints. Her PIP contractures were ∼90 degrees

• br Introduction Detection of driver mutations

  2019-10-31

  

  Introduction Detection of driver mutations in patients with advanced non-small cell lung cancer (NSCLC) is critical because they receive great benefit from kinase inhibitors [[1], [2], [3], [4]]. However, it is often difficult to obtain tumor tissue in advanced NSCLC patients. Cell-free DNA (cfDN

• EBI and its ligand s

  2019-10-31

  

  EBI2 and its ligand(s) EBI2 was found in a screen of upregulated genes in human B cells upon infection with EBV [1]. EBI2 is a G-protein (Gαi type) coupled receptor [2] but as long as 18 years after its discovery the nature of its ligand remained undisclosed. With the help of transfected cell lines

• LY 255283 br RING dimerization RING type domains are found i

  2019-10-31

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain LY 255283 (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (sho

• br Introduction Melatonin mainly originates from the

  2019-10-31

  

  Introduction Melatonin mainly originates from the pineal gland (Reiter, 1991) and is well known for its physiological functions in the regulation of circadian rhythms (Cajochen et al., 2003) and as a potent free radical scavenger and broad-spectrum antioxidant in mammals (Paradies et al., 2010, T

• The data from the Sur lab have showed DNA

  2019-10-31

  

  The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty na+/ca2+ exchanger synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Upstrea

• Materials and methods Between January

  2019-10-31

  

  Materials and methods Between January 2006 and December 2008, 34 patients with GBM were treated with postoperative three-dimensional (3D) radiotherapy at Tartu University Hospital or North Estonian Medical Centre. Characteristics of patients are listed in Table 1. Results Discussion Radioth

• In the case of high fidelity

  2019-10-31

  

  In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this

• Extracellular uridine can be transported across the cell mem

  2019-10-31

  

  Extracellular uridine can be transported across the cell membrane to enter the nucleotide salvage pathway. A colon cancer cell line supplemented with uridine was capable of growing normally in the presence of 1 μM brequinar (Peters et al., 1992). The supplemented uridine may be transported into the

• Targeting both PARP and DHODH for anti cancer

  2019-10-31

  

  Targeting both PARP-1 and DHODH for anti-cancer therapy would certainly be beneficial as these enzymes share a common role in the DNA replication and repair mechanisms which are involved in the hyper-proliferation of cancer cells. Since benzimidazole-containing compounds have been reported to show g

• KSTDs are generally reported to be intracellular enzymes

  2019-10-31

  

  — Δ1-KSTDs are generally reported to be intracellular enzymes, either soluble or bound to subcellular particles. For instance, the enzymes from C. testosteroni ATCC 11996 and ATCC 17410 [50,90,99], R. equi [29], and N. simplex ATCC 6946 [52] were particulate-bound. On the other hand, the Δ1-KSTDs f

• br Concluding Remarks Synthetic cytokine biology has become

  2019-10-31

  

  Concluding Remarks Synthetic cytokine biology has become an important research area with novel solutions and ideas for therapeutic approaches, for example, synthekines, fusokines, immunocytokines, neoleukins, MESA receptors, or synthetic Notch or cytokine receptors. In addition to their huge impa

• Ligand binding RTK activation induces

  2019-10-31

  

  Ligand binding (RTK activation) induces the endocytic internalization of RTKs, and this has been demonstrated for CSF-1R [15], [16], [17]. Endocytosed RTKs are targeted to the lysosome, which we and others have established to be dependent on ubiquitination via CBL-family and recognition by ESCRT com

• Compounds were screened for their

  2019-10-31

  

  Compounds were screened for their activity against the hERG channel, with the 2,3-Cl compounds more active here than the 2,4-F compounds. The homopiperazine examples (, , , ) showed increased hERG activity relative to the corresponding piperazines. The cell data for the 6,7-dimethoxyquinoline compo

• In general cellular senescence is considered a programmed re

  2019-10-30

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

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